Epabis dispensable for mouse spermatogenesis and male fertility
نویسندگان
چکیده
منابع مشابه
The Essential Role of Dicer in Spermatogenesis and Male Fertility
TIIVISTELMÄ ABBREVIATIONS LIST OF ORIGINAL PUBLICATIONS
متن کاملCaMKIV/Gr is dispensable for spermatogenesis and CREM-regulated transcription in male germ cells.
The calcium/calmodulin-dependent protein kinase type IV/Gr (CaMKIV/Gr) is expressed in male germ cells and spermatids and has been implicated in controlling the differentiation of germ cells into mature spermatozoa. The function of CaMKIV/Gr in spermatogenesis was investigated using CaMKIV/Gr-deficient mice generated by targeted gene disruption. CaMKIV/Gr-deficient males exhibited normal sperma...
متن کاملEpigenetic dynamics and interplay during spermatogenesis and embryogenesis: implications for male fertility and offspring health
Mapping epigenetic modifications and identifying their roles in the regulation of spermatogenesis and embryogenesis are essential for gaining fundamental medical understandings and for clinical applications. More and more evidence has shown that specific epigenetic modifications are established during spermatogenesis, which will be transferred into oocyte via fertilisation, and play an importan...
متن کاملLRGUK-1 Is Required for Basal Body and Manchette Function during Spermatogenesis and Male Fertility
Male infertility affects at least 5% of reproductive age males. The most common pathology is a complex presentation of decreased sperm output and abnormal sperm shape and motility referred to as oligoasthenoteratospermia (OAT). For the majority of OAT men a precise diagnosis cannot be provided. Here we demonstrate that leucine-rich repeats and guanylate kinase-domain containing isoform 1 (LRGUK...
متن کاملDeleterious effects of obesity upon the hormonal and molecular mechanisms controlling spermatogenesis and male fertility.
Worldwide obesity rates have nearly doubled since 1980 and currently over 10% of the population is obese. In 2008, over 1.4 billion adults aged 20 years and older had a body mass index or BMI above a healthy weight and of these, over 200 million men and nearly 300 million women were obese. While obesity can have many ramifications upon adult life, one growing area of concern is that of reproduc...
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ژورنال
عنوان ژورنال: Molecular Reproduction and Development
سال: 2014
ISSN: 1040-452X
DOI: 10.1002/mrd.22319